TABLE 2.
Reasons for PIs and acceptance rate.
| Intervention type | Number | Percent [%] | Acceptance rate a [%] |
|---|---|---|---|
| Administration (total) | 10 | 0.8 | 75.0 |
| Administration (route) | 4 | 0.3 | 100.0 |
| Request/Query concerning administration/compatibility | 4 | 0.3 | - |
| Administration (duration) | 1 | 0.1 | 0.0 |
| Incompatibility or incorrect preparation/reconstitution | 1 | 0.1 | 100.0 |
| Adverse drug reaction (total) | 4 | 0.3 | 100.0 |
| Contraindication (total) | 32 | 2.4 | 93.8 |
| Dose (total) | 393 | 29.6 | 93.0 |
| (Inappropriate) administration interval | 130 | 9.8 | 93.9 |
| (Inappropriate) dose | 132 | 9.9 | 92.1 |
| Failure to adjust dose for organ dysfunction | 79 | 6.0 | 90.8 |
| TDM not performed or neglected | 52 | 3.9 | 96.2 |
| Drugs (total) | 568 | 42.7 | 93.0 |
| (Clear) indication, but no drug prescribed | 243 | 18.3 | 92.4 |
| (Clear) indication not (or no longer) given | 128 | 9.6 | 89.6 |
| Inappropriate (or not most suitable) drug in terms of indication | 75 | 5.6 | 89.2 |
| Inappropriate (or not most suitable) drug formulation in terms of indication | 50 | 3.8 | 90.0 |
| Double prescription | 36 | 2.7 | 100.0 |
| Inappropriate (or not most suitable) drug in terms of costs | 20 | 1.5 | 95.0 |
| Prescription/Documentation incomplete/incorrect | 5 | 0.4 | 80.0 |
| Generic/Therapeutic substitution | 7 | 0.5 | 100.0 |
| Drug allergy or medical history not considered | 3 | 0.2 | 50.0 |
| Transcription error | 1 | 0.1 | 0.0 |
| Interaction (total) | 73 | 5.5 | 95.7 |
| Other (total) | 249 | 18.7 | 89.3 |
| Procurement/Costs | 98 | 7.4 | 100.0 |
| Advisory service/Drug choice | 86 | 6.5 | 83.1 |
| Advisory service/Drug dose | 64 | 4.8 | 88.9 |
| Failure to discontinue relevant drugs pre-/perioperatively | 1 | 0.1 | 100.0 |
| Total | 1,329 | 100.0 | 91.9 |
a
Acceptance rate of PIs refers to n = 1,180, excluding PIs where only information was provided to physicians or nurses.