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. Author manuscript; available in PMC: 2022 Nov 28.
Published in final edited form as: Shock. 2020 Nov;54(5):595–605. doi: 10.1097/SHK.0000000000001531

Figure 1. Role of Complement in Polymicrobial Sepsis.

Figure 1.

Infectious sepsis robustly activates the classical and alternative and lectin complement pathways, generating C5a which reacts with its receptors (C5aR1, C5aR2) on neutrophils and macrophages. This leads to formation of neutrophil extracellular traps (NETs) and macrophage extracellular traps (METs)that in release of histones.