TABLE 2 -.
Alcohol Drinking prior to Stress Exposure
| Study | Species Strain | Sex | Alcohol Access | Frequency and Length of Initial Alcohol Exposure prior to Stress | Stressor | Frequency and Length of Stress Exposure | Stress-induced alcohol intake? |
|---|---|---|---|---|---|---|---|
| Farook et al. (2009) | Mice (C57BL/6J) | M | Continuous TBC |
Daily, 7 days | Physical restraint | Daily for 5 days | Yes |
| Edwards et al. (2013) | Rats (Wistar) | M | Limited, 30 min, two-choice operant | Daily, 15 days | Predator odor | Once, 15 min | Yes |
| Cozzoli et al. (2014) | Mice (C57BL/6J) | M/F | Limited 2 hr (DID) |
Daily, 15 days | One of each: Tail suspension Physical restraint Predator odor Foot shock Tail pinch |
Each stressor applied at least 5 drinking sessions apart. | Yes (for predator odor and foot shock) |
| Walker et al. (2015) | Mice (C57BL/6J) | M | Continuous TBC |
Daily, 3 weeks | Physical restraint + Forced swim | Daily, 7 days Daily, 2 days |
No No |
| Anderson et al. (2016) | Mice (C57BL/6J) | M | Continuous TBC Intermittent TBC Limited, 2 hr (DID) Intermittent and limited (TBC, 2 hr) +alcohol vapor |
Daily, 7 days 3x week, 1 week Daily, 1 week 3x week, 6 weeks Daily, 16hrs, 4 days |
Forced swim Forced swim Forced swim Forced swim |
3x week, for 4 weeks Same as above Daily, for 4 weeks, Same as above - cycle repeated 4 times on alternate weeks |
No No No Yes |
| Lopez et al. (2016) | Mice (C57BL/6J) | M | Limited, TBC, 2 hr (DID) Limited, TBC, 2 hours (DID) + alcohol vapor exposure |
Daily, 6 weeks Daily, until stable Daily, 16hrs, for 4 days |
Physical restraint Social defeat Forced swim Social defeat Forced swim |
Daily, 5 days Daily, 5 days Daily, 5 days Daily, 5 days, repeated 4x on alternate weeks Daily, 5 days, repeated 4 x on alternate weeks |
No No No No Yes |
| Manjoch et al., 2016 | Rats (Sprague-Dawley) | M | Continuous TBC | Daily, at least 7 days | Predator odor | Once, 15 min Re-exposed to context 2×15 min |
Yes Yes |
| Finn et al., 2018 | Mice (C57BL/6J) | M/F | Intermittent limited (single sipper, 30 min), then, continuous TBC | Every 3rd day, 7 sessions total Daily, 3 weeks |
Predator odor | Every 2–3 days, 30 min, 4x. | Yes |
TBC: two-bottle choice; DID: drinking in the dark.