Skip to main content
. Author manuscript; available in PMC: 2022 Nov 28.
Published in final edited form as: J Invest Dermatol. 2021 Dec 7;142(7):1882–1892.e5. doi: 10.1016/j.jid.2021.11.027

Figure 3. Knockdown of NUMB promotes melanoma metastasis in vivo.

Figure 3.

(a) H&E staining of lung tissue sections showing metastatic lesions in in vivo metastasis assays. Mice were injected intravenously with WM1799 melanoma cells transduced with a control shRNA or with shRNAs targeting NUMB. Arrowheads indicate metastasis. Bar = 1 mm. (b) Quantification of the percentage of metastatic area per lung tissue section (n = 10). (c) Quantification of the number of lung metastases per mouse lung section (n = 10). shLuc, short hairpin RNA targeting firefly luciferase; shRNA, short hairpin RNA.