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. 2022 Aug 3;21(24):2575–2589. doi: 10.1080/15384101.2022.2105087

Figure 1.

Figure 1.

CircFARSA was highly expressed in NSCLC tissues and cell lines. (a), CircFARSA is derived from back-splicing of exons 5, 6, and 7 of FARSA gene. The back-splicing Orange arrow represents the special splicing junction of circFARSA. (b), CircFARSA expression in NSCLC tissues (n = 486) and normal tissues (n = 338) was analyzed from the Gene Expression Profiling Interactive Analysis (GEPIA) database. (c), The expression of circFARSA in NSCLC tumor tissues (n = 40) and matched adjacent normal tissues (n = 40) was examined using qRT-PCR. (d), Overall survival between NSCLC patients with high circFARSA expression and those with low expression was analyzed using Kaplan-Meier curves analysis. (e), CircFARSA levels in NSCLC cell lines and human bronchial epithelial cell line (BEAS-2B) were detected using qRT-PCR. (f and g), The RNase R assay was performed to determine the stability of circFARSA in NCI-H1299 and H125 cells. *P < 0.05, ***P < 0.001, Compared with the Normal group. #P < 0.05, ##P < 0.01, Compared with the BEAS-2B cells.