Table 4.
Fv domain electrostatic descriptors and ABSASA hydrophobicity scores of three approved therapeutic mAbs. Fv domain homology model surface map: Green = hydrophobic side chains, red = acidic side chains (D&E), blue = basic side chains (R&K) and cyan = basic side chain (H).
| Identifier | Infliximab | Tocilizumab | Rituximab |
|---|---|---|---|
| FV domain homology model (top down view) |
 |
 |
 |
| ABSASA Hydrophobicity (Å2) |
592.6 | 474.4 | 531.3 |
| Acidic residues (D&E) |
22 | 13 | 12 |
| Basic residues (R&K) |
19 | 19 | 18 |
| Basic residues (R&K&H) |
23 | 21 | 20 |
| Net charge (pH 7.4) |
−3 | 6 | 6 |
| Net charge (pH 5.0) |
1 | 8 | 8 |