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. 2022 Nov 22;14(1):2143218. doi: 10.1080/19490976.2022.2143218

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — 5-ASA dampens the aEPEC-induced pro-inflammatory epithelial response. (a) IL-8 secretion of human primary colon epithelial cells (HCEC-1CT) infected with EspG2- (purple) and EspV-positive (blue) aEPEC strains, normalized to untreated cells (black). (b) IL-8 secretion of primary colon epithelial cells infected with EspV-positive AEEC strains, without (blue) and with 5-ASA (light blue), normalized to untreated cells. (c) IL-8 secretion of primary colon epithelial cells infected with EspG2-positive AEEC strains, without (purple) and with 5-ASA (light purple), normalized to untreated cells. (d) PAK1 expression of primary colon epithelial cells infected with aEPEC, relative to untreated cells with (blue) and without (Orange) 5-ASA, tEPEC (Orange line). (e) PAK2 expression of primary colon epithelial cells infected with aEPEC, relative to untreated cells with (blue) and without (Orange) 5-ASA. (a-e) Values for the reference strain tEPEC-E2348/69 are visualized with an Orange line. (a-e) Data Points from the same strains are connected with a gray line. Statistical analysis: (a) unpaired t-test, (b-e) paired t-test, (a-c) Log₁₀ transformed y-axis; *p ≤ .05, **p ≤ .01, ***p ≤ .001.