GI50 values (M) mean ± SD | Selectivity indices (SI) | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MCF-7 | HCT-116 | MRC-5 | MCF-7 | HCT-116 | MW | c log Pc | LE (MCF-7) | LE (HCT-116) | tPSAd | Nrotd | HBAd | HBDd | |
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a′ | 1.7 ± 0.3 | 4.2 ± 1.0 | 11.6 ± 0.6 | 6.8 | 2.8 | 394.3 | 4.24 | 0.29 | 0.27 | 89 | 4 | 4 | 1 |
b′ | 3.9 ± 0.5 | 1.6 ± 0.2 | 19.5 ± 0.3 | 5 | 12.2 | 389.3 | 4.35 | 0.33 | 0.36 | 118 | 4 | 4 | 1 |
c′ | 4.3 ± 0.3 | 6.2 ± 0.5 | 7.6 ± 0.1 | 1.8 | 1.2 | 389.3 | 4.35 | 0.33 | 0.32 | 118 | 4 | 4 | 1 |
d′ | 9.0 ± 1.2 | 4.4 ± 0.2 | 22.5 ± 02 | 2.5 | 5.1 | 339.4 | 4.35 | 0.30 | 0.32 | 130 | 4 | 5 | 1 |
cisplatinb | 7.5 ± 0.7 | 9.8 ± 0.2 | 9.7 ± 0.4 | 1.3 | 0.9 |