Table 3.

Association Between Acute/Upstream Inflammation (Composite 1) and Level and Change in Cognitive Function

	Global Cognition	Episodic Memory	Semantic Memory	Working Memory	Perceptual Speed	Visuospatial Ability
Model Term	β ± SE	β ± SE	β ± SE	β ± SE	β ± SE	β ± SE
Time	−0.144 ± 0.017***	−0.124 ± 0.024***	−0.171 ± 0.024***	−0.119 ± 0.022***	−0.122 ± 0.018***	−0.053 ± 0.020**
Acute/Upstream	−0.068 ± 0.037	−.072 ± 0.047	−0.092 ± 0.045*	−0.010 ± 0.052	−0.096 ± 0.048*	−0.044 ± 0.049
Acute/Upstream x Time	−0.003 ± 0.007	−0.003 ± 0.009	−0.0004 ± 0.009	−0.004 ± 0.006	−0.002 ± 0.005	−0.003 ± 0.005

^*Denotes significant result at p < 0.05

^**Denotes significant result at p < 0.025

^***Denotes significant result at p < 0.0001.

Note: Results from six separate linear mixed models are shown, where each model additionally adjusted for age, sex, education, vascular risk factors, body mass index, statin medications, and analgesic medications.