Table 4.

Association Between Chronic/Downstream Inflammation (Composite 2) and Level and Change in Cognitive Function

	Global Cognition	Episodic Memory	Semantic Memory	Working Memory	Perceptual Speed	Visuospatial Ability
Model Term	β ± SE	β ± SE	β ± SE	β ± SE	β ± SE	β ± SE
Time	−0.144 ± 0.017***	−0.126 ± 0.024***	−0.172 ± 0.024***	−0.118 ± 0.021***	−0.122 ± 0.018***	−0.052 ± 0.019**
Chronic/Downstream	−0.029 ± 0.036	−0.008 ± 0.046	−0.023 ± 0.044	−0.066 ± 0.050	−0.040 ± 0.047	−0.042 ± 0.048
Chronic/Downstream x Time	−0.018 ± 0.007**	−0.020 ± 0.009*	−0.016 ± 0.009	−0.017 ± 0.006**	−0.008 ± 0.005	−0.004 ± 0.005

^*Denotes significant result at p < 0.05

^**Denotes significant result at p < 0.025

^***Denotes significant result at p < 0.0001

Note: Results from six separate linear mixed models are shown, where each model additionally adjusted for age, sex, education, vascular risk factors, body mass index, statin medications, and analgesic medications.