Table 1. Table of the top 10 KEGG signaling pathways.

ID	Description	p.adjust	Matched target
hsa04933	AGE-RAGE signaling pathway in diabetic complications	4.45E-28	BCL2, BAX, JUN, CASP3, RELA, AKT1, VEGFA, CCND1, MMP2, MAPK1, L6, ICAM1, STAT1, F3, IL1B, CCL2, SELE, VCAM1, CXCL8, NOS3, THBD, SERPINE1, IL1A, COL3A1, MAPK14, MAPK8
hsa05417	Lipid and atherosclerosis	3.81E-23	RXRA, BCL2, BAX, CASP9, UN, CASP3 CASP8, RELA, AKT1, MMP9, MAPK1 , IL6, MMP1, PPARG, ICAM1, CD40LG, MMP3, IL1B, CCL2, SELE, VCAM1, CXCL8, NOS3, NFE2L2, CXCL2 CHUK, MAPK14, MAPK8, APOB
hsa05418	Fluid shear stress and atherosclerosis	3.91E-20	BCL2, JUN, RELA, AKT1, VEGFA, MMP2, MMP9, HMOX1, ICAM1, IFNG IL1B, CCL2, SELE, VCAM1, NOS3, PLAT, THBD, IL1A, NFE2L2, CHUK, KDR, MAPK14, MAPK8
hsa04657	IL-17 signaling pathway	9.84E-20	PTGS2, JUN, CASP3, CASP8, RELA, MMP9, MAPK1, IL6, MMP1, IFNG, IL4, MMP3, IL1B, CCL2, CXCL8, CXCL2 CXCL10, CHUK, MAPK14, MAPK8
hsa04668	TNF signaling pathway	3.31E-18	PTGS2, JUN, CASP3, CASP8, RELA, AKT1, MMP9, MAPK1, IL6, ICAM1, MMP3, IL1B, CCL2, SELE, VCAM1, CXCL2, CXCL10, CHUK, MAPK14, MAPK8
hsa05161	Hepatitis B	2.98E-16	BCL2, BAX, CASP9, JUN, CASP3, CASP8, RELA, AKT1, CDKN1A, MMP9, MAPK1, RB1, IL6, PCNA, BIRC5, STAT1, CXCL8, CHUK, MAPK14, CCNA2, MAPK8
hsa05167	Kaposi sarcoma-associated herpesvirus infection	7.05E-16	PTGS2, BAX, CASP9, JUN, CASP3, CASP8, RELA, AKT1, VEGFA, CCND1, CDKN1A, MAPK1, RB1, IL6, ICAM1, HIF1A, STAT1, CXCL8, CXCL2, CHUK, MAPK14, MAPK8
hsa04066	HIF-1 signaling pathway	7.80E-16	BCL2, NOS2, RELA, EGFR, AKT1, VEGFA, CDKN1A, MAPK1, IL6, ERBB2, HMOX1, IFNG, INSR, EGF, HIF1A, NOS3, SERPINE1, HK2
hsa05215	Prostate cancer	2.03E-15	BCL2, CASP9, RELA, EGFR, AKT1, CCND1, CDKN1A, MMP9, MAPK1, RB1, MDM2, ERBB2, MMP3, PLAU, EGF, PLAT, CHUK
hsa05219	Bladder cancer	2.25E-15	EGFR, VEGFA, CCND1, CDKN1A, MMP2 , MMP9, MAPK1, RB1, MDM2, MMP1 ERBB2, EGF, CXCL8

Note: List of genes in the first 10 pathways of KEGG, where the Genes marked in bold italics represent the distribution of 6 HUB genes in each pathway.