Table 4. Number of STAT3 mutation carriers in MS patients and controls.
MS (n = 94) | Ctrl (n = 99) | p-value* | |
---|---|---|---|
Any mutation | 26 (28%) | 24(24%) | 0.62 |
Median age | 49 yrs | 47 yrs | |
Any mutations ≥2 | 9 (9.6%) | 2 (2.0%) | 0.03 (pcorr = 0.12) |
Median age | 50 yrs | 58 yrs | |
Mutation in COSMIC/OMIM | 19 (20%) | 22 (22%) | 0.86 |
Median age | 51 yrs | 51 yrs | |
Other mutations** | 9 (9.6%) | 3 (3.0%) | 0.08 (pcorr = 0.24) |
Median age | 48 yrs | 39 yrs |
* Fisher’s exact test, corrected, when necessary by the number of comparisons (4);
**Mutation not found in COSMIC/OMIM. COSMIC, Catalogue Of Somatic Mutations In Cancer; OMIM, Online Mendelian Inheritance in Man.