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. 2022 Nov 28;17(11):e0278245. doi: 10.1371/journal.pone.0278245

Table 4. Number of STAT3 mutation carriers in MS patients and controls.

MS (n = 94) Ctrl (n = 99) p-value*
Any mutation 26 (28%) 24(24%) 0.62
 Median age 49 yrs 47 yrs
Any mutations ≥2 9 (9.6%) 2 (2.0%) 0.03 (pcorr = 0.12)
 Median age 50 yrs 58 yrs
Mutation in COSMIC/OMIM 19 (20%) 22 (22%) 0.86
 Median age 51 yrs 51 yrs
Other mutations** 9 (9.6%) 3 (3.0%) 0.08 (pcorr = 0.24)
 Median age 48 yrs 39 yrs

* Fisher’s exact test, corrected, when necessary by the number of comparisons (4);

**Mutation not found in COSMIC/OMIM. COSMIC, Catalogue Of Somatic Mutations In Cancer; OMIM, Online Mendelian Inheritance in Man.