Table 1. Predicted antiviral activities (% inhibition) of cytidine derivatives 2–15, remdesivir, and AZT.
Compounds | General | HBV | HCV | HHV | HIV |
---|---|---|---|---|---|
1 | - | - | - | - | - |
2 | 56.694 | 24.616 | 52.294 | 39.139 | 60.776 |
3 | 50.334 | 25.168 | 44.745 | 68.231 | 69.760 |
4 | 51.770 | 25.164 | 44.746 | 65.844 | 70.174 |
5 | 7.689 | 20.217 | 18.367 | 48.010 | 71.148 |
6 | 5.209 | 22.034 | 17.707 | 32.962 | 62.485 |
7 | 8.964 | 19.478 | 38.064 | 46.137 | 65.673 |
8 | 54.817 | 25.306 | 58.732 | 51.525 | 55.146 |
9 | 2.101 | 19.505 | 44.539 | 44.016 | 68.671 |
10 | 2.327 | 19.694 | 37.089 | 45.767 | 68.719 |
11 | 50.134 | 24.790 | 47.106 | 60.254 | 62.961 |
12 | 4.310 | 20.681 | 37.091 | 43.999 | 69.047 |
13 | 3.345 | 19.376 | 56.274 | 81.466 | 65.758 |
14 | 47.021 | 26.981 | 46.291 | 75.321 | 63.214 |
15 | 61.039 | 18.367 | 53.816 | 61.409 | 63.427 |
Remdesivir | 48.642 | 22.443 | 66.968 | 36.291 | 69.503 |
AZT | 87.038 | 19.619 | 24.962 | 28.728 | 92.855 |
HBV = Hepatitis B virus; HCV = Hepatitis C virus; HHV = Human herpesvirus; HIV = Human immunodeficiency virus.