Table 3.

Association of Race and Sex with Sudden Cardiac Death among Participants without Baseline Cardiovascular Disease

	Men			Women
Participants (n=22,507)	White (n=5,926)	Black (3,329)	p-value	White (n=7,165)	Black (6,087)	p-value
Sudden Cardiac Death Events, n	46	54		21	53
Incidence Rate* (per 1,000 py)	1.0 (0.8, 1.4)	2.5 (1.9, 3.2)		0.4 (0.3, 0.7)	1.4 (1.0, 18)
Unadjusted; HR (95% CI)	1.00	2.26 (1.52, 3.34)	<0.001	1.00	3.08 (1.86, 5.11)	<0.001
Model 1†	1.00	2.00 (1.32, 3.04)	0.001	1.00	3.00 (1.77, 5.07)	<0.001
Model 2‡	1.00	1.62 (1.04, 2.50)	0.032	1.00	2.27 (1.30, 3.94)	0.004
Model 3§	1.00	1.72 (1.10, 1.67)	0.017	1.00	2.39 (1.36, 4.20)	0.002
Model 4‖	1.00	1.63 (1.04, 2.55)	0.033	1.00	2.28 (1.30, 4.02)	0.004
Model 5#	1.00	1.69 (1.08, 2.63)	0.003	1.00	2.39 (1.36, 4.19)	0.021

^*Age-adjusted

^†Model 1 adjusts for age, region, education, income, and health insurance

^‡Model 2 adjusts for Model 1 plus standard coronary heart disease risk factors and preventive therapies including systolic blood pressure, diastolic blood pressure, total cholesterol, HDL, diabetes, body mass index, statins, and use of antihypertensive medication

^§Model 3 adjusts for Model 2 plus ACR, eGFR, LVH, and atrial fibrillation

^‖Model 4 adjusts for Model 3 plus behavioral factors including smoking, alcohol use, physical activity, perceived stress and elevated depressive symptoms

^#Model 5 adjusts for Model 4 plus intervening non-fatal myocardial infarction and/or heart failure hospitalization as time-variant covariates and the competing risks of non-SCD