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. 2022 Nov 14;18(11):e1010700. doi: 10.1371/journal.ppat.1010700

Fig 4. Mitochondrial ROS are required for the ability of PMNs to kill S. pneumoniae.

Fig 4

(A) WT (C57BL/6) bone-marrow derived PMNs were treated with vehicle control (VC), the mitochondrial ROS scavenger MitoTEMPO or Euk134 or the NADPH oxidase inhibitor DPI and then infected with S. pneumoniae TIGR4. (B) WT (C57BL/6) bone-marrow derived PMNs were treated with vehicle control (VC) or MitoTEMPO and infected with S. pneumoniae D39, 19F, or 23F. The percentage of bacterial killing was determined with respect to no PMN controls under the same treatment conditions. Data are pooled from (A) n = 5 and (B) n = 3 separate experiments. Bar graphs represent the mean +/-SD. * indicates significant differences between the indicated groups as determined by (A) one-way ANOVA followed by Tukey’s multiple comparisons test or (B) unpaired Student’s t-test. n.s. indicates not significant.