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. 2022 Nov 14;18(11):e1010700. doi: 10.1371/journal.ppat.1010700

Fig 10. A2BR impairs host resistance against systemic infection with S. pneumoniae.

Fig 10

(A-B) WT C57BL/6 mice treated with vehicle control or the mitochondrial ROS scavenger MitoTEMPO were infected with S. pneumoniae D39 intra-peritoneally. (A) survival as well as (B) bacteremia was followed over time. Data shown are from two separate experiments with n = 5 mice per group. * indicates significant differences as measured by Log-Rank Mantle Cox test (A) and Mann-Whitney test (B). (C-D) A2BR-/- and WT C57BL/6 mice treated with vehicle control or the mitochondrial ROS scavenger MitoTEMPO were infected with S. pneumoniae TIGR4 intra-peritoneally. (C) survival as well as (D) bacteremia and clearance of infection (E) was followed over time. Data shown are from three separate experiments with n = 12 mice per group. * indicates significant differences as measured by Log-Rank Mantle Cox test (C) and Kruskal Wallis test (D). $ indicates significant differences between the mouse groups in the clearance of bacteremia as measured by Fisher’s exact test (E). n.s. indicates not significant.