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. Author manuscript; available in PMC: 2023 Aug 4.
Published in final edited form as: Eur Respir J. 2022 Aug 4;60(2):2101865. doi: 10.1183/13993003.01865-2021

TABLE 2.

Relationship between the location of eosinophils within the airway wall and features of airway hyperresponsiveness#

Methacholine PC20 Severity of EIB (AUC30) Max fall in FEV1
All subjects Asthma group All subjects Asthma group All subjects Asthma group
r2 p-value r2 p-value r2 p-value r2 p-value r2 p-value r2 p-value
Intraepithelial eosinophils
 Volume (cells·mm−3) 0.18 <0.01 0.06 0.19 0.17 0.01 0.10 0.09 0.21 <0.01 0.13 0.06
 Basal lamina (×102 cells·mm−2) 0.11 0.04 0.05 0.20 0.27 <0.01 0.21 0.01 0.28 <0.01 0.22 0.01
Subepithelial eosinophils
 Volume (cells·mm−3) 0.11 0.03 0.07 0.15 0.06 0.11 0.02 0.40 0.12 0.03 0.07 0.16
 Basal lamina (×102 cells·mm−2) 0.08 0.06 0.06 0.17 0.03 0.22 0.01 0.52 0.03 0.22 0.01 0.50

Bold type represents statistical significance. PC20: provocative concentration causing a 20% fall in forced expiratory volume in 1 s (FEV1); EIB: exercise-induced bronchoconstriction; AUC30: area under the FEV1 time curve.

#:

assessed using a simple linear regression with the methacholine PC20, the severity of EIB over the first 30 min after exercise challenge (AUC30), and the max fall in FEV1 representing the dependent variables.