Table 3.
Univariate and multivariate Cox regression analyses for overall survival (n = 135).
| Variables | Overall survival | |||||
|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | |||||
| HR | 95% CI | P | HR | 95% CI | P | |
| Sirt6 levels (low vs high) | 2.69 | 1.498–4.829 | .001 | 2.030 | 1.106–3.726 | .022 |
| Age (<60 vs ≥60) | 1.329 | 0.718–2.458 | .365 | |||
| Gender (female vs male) | 1.323 | 0.728–2.406 | .358 | |||
| CEA levels (high vs low) | 2.988 | 1.262–7.076 | .013 | 2.882 | 1.202–6.907 | .018 |
| CA 19-9 levels (high vs low) | 1.044 | 0.584–1.867 | .885 | |||
| CA 72-4 levels (high vs low) | 1.726 | 0.856–3.480 | .127 | |||
| Tumor size (<4 cm vs ≥4 cm) | 1.969 | 1.088–3.565 | .025 | |||
| Lauren classification (intestinal vs diffuse) | 2.108 | 1.175–3.782 | .012 | |||
| Pathological differention (well + moderate vs poor) | 1.976 | 1.107–3.527 | .021 | |||
| Lymph nodes metastasis (negative vs positive) | 2.147 | 1.211–3.808 | .009 | |||
| TNM stage (I and II vs III and IV) | 2.024 | 1.135–3.610 | .017 | 2.332 | 1.015–5.354 | .046 |
CA 19-9 = carbohydrate antigen 19-9, CA 72-4 = carbohydrate antigen 72-4, CEA = carcino-embryonic antigen, Sirt6 = sirtuin 6, TNM = tumor node metastasis.