Table 3.

The binding energy of top 5 compounds of HF-NR with VD-related core targets.

	Molecule name	CID	Core gene docking score (kcal/mol)
			IL6	VEGFA	CASP3	MAPK8	EGFR
Core components	Quercetin	5280343	−4.39	−5.73	−4.04	−3.74	−3.32
	Kaempferol	5280863	−5.45	−6.27	−4.00	−4.82	−4.58
	Luteolin	5280445	−5.11	−5.63	−4.58	−5.29	−4.83
	Anhydroicaritin	14583584	−4.71	−4.56	−3.58	−4.35	−4.03
	β-Sitosterol	521199	−5.15	−5.94	−5.39	−3.32	−5.15

CASP3 = caspase 3, EGFR = epidermal growth factor receptor, HF-NR = Epimedii Folium and Notoginseng Radix, IL-6 = interleukin 6, MAPK8 = mitogen-activated protein kinase 8, VEGF-A = vascular endothelial growth factor-A, VD = vascular dementia.