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Effect of downregulation of PMA-sensitive PKCs on R. rickettsii-induced TF activity. EC were treated with PMA (100 ng/ml) for 48 h and infected with R. rickettsii for 8 h or else rechallenged with PMA (20 ng/ml). PMA and R. rickettsii-induced TF activities in untreated EC were assigned a value of 100% (open bars), and changes are expressed relative to this value (shaded bars). The values shown are the mean ± the SEM (n ≥ 9).
