Table 5.
Effect of bromelain (Bro), aluminum chloride (AlCl3), and their combination (Bro+AlCl3) on enzyme activities and protein content in serum and liver of male rats.
| Parameters | Groups | |||
|---|---|---|---|---|
| Cont. | Bro | AlCl3 | Bro+AlCl3 | |
| Serum | ||||
| AST (U/l) % change |
53.12c ± 1.12 | 51.20c ± 1.51 (-3.62%) |
76.88a ± 2.29 (+44.74%) |
65.97b ± 1.75 (+24.19%) |
| ALT (U/l) % change |
58.57c ± 1.28 | 54.70c ± 0.84 (-6.61%) |
82.89a ± 2.42 (+41.54%) |
71.55b ± 2.37 (+22.17%) |
| LDH (U/l) % change |
585c ± 14.32 | 563c ± 14.21 (-3.71%) |
823a ± 18.84 (+40.82%) |
713b ± 20.03 (+21.95) |
| ALP (U/l) % change |
59.01c ± 1.90 | 58.20c ± 2.09 (-1.38%) |
83.80a ± 2.32 (+42.01%) |
69.47b ± 2.05 (+17.72%) |
| Bilirubin (mg/dl) % change |
0.730c ± 0.017 | 0.732c ± 0.016 (+0.25%) |
1.02a ± 0.027 (+39.13%) |
0.871b ± 0.028 (+19.29%) |
| Liver | ||||
| AST (U/mg protein) % change |
125a ± 3.75 | 131.32a ± 3.15 (+4.79%) |
80.43c ± 1.78 (-35.78%) |
102b ± 2.88 (-18.54%) |
| ALT (U/mg protein) % change |
162a ± 5.03 | 154a ± 3.29 (-5%) |
99c ± 3.40 (-38.73%) |
131b ± 4.21 (-19.12%) |
| LDH (U/mg protein) % change |
1001c ± 34.04 | 940c ± 31.17 (-6.07%) |
1366a ± 37.79 (+36.51%) |
1206b ± 27.83 (+20.58%) |
| ALP (U/mg protein) % change |
344a ± 9.98 | 374a ± 11.18 (+8.87%) |
216c ± 6.21 (-37.32%) |
291b ± 7.68 (-15.33%) |
| Protein (mg/g tissue) % change |
194a ± 2.44 | 197a ± 4.29 (+1.48%) |
128c ± 4.45 (-34.15%) |
163b ± 4.02 (+16.10%) |
Values are expressed as means ± SEM; n = 7 for each treatment group. abc Mean values within a row not sharing a common superscript letter were significantly different, P < 0.05. Statistically significant variations are compared as follows: Bromelain and AlCl3 groups are compared vs control group while Bromelain+AlCl3 group is compared vs AlCl3 group.