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. 2022 Sep 7;15(6):1296–1308. doi: 10.1038/s41385-022-00563-2

Fig. 2. Two main anti-inflammatory Mφ subpopulations with a unique transcriptional state are present during the resolution of muscularis inflammation.

Fig. 2

a UMAP of reclustered monocyte/Mφ subpopulations from Fig. 1a from the healthy muscularis, 24 h and 72 h post-injury from WT mice. b Heatmap of typical monocyte and Mφ markers including MHCII genes. c UMAPs of time-dependent infiltration of monocyte and Mφ subsets upon muscularis inflammation. d Cell fraction of each subcluster relative to the total number of monocytes/Mφs at different time points after muscularis inflammation. e Dotplot showing expression of selected differentially expressed genes in each subcluster. f Heatmap of regulon activity per cluster according to SCENIC analysis. g Pseudotime analysis of monocytes/Mφs at different time points after muscularis inflammation. h Heatmap of gene expression showing the top 50 genes of different branches of the pseudotime trajectory tree.