Table 6.
Median annual RNFL thickness and macular volume changes seen in the three participant groups.
| Region | Median rate of change in RNFL thickness in µm/year (IQR) | |||
|---|---|---|---|---|
| Healthy volunteers | Participants with MS | |||
| OS | OD | OS | OD | |
| Global | 0 (1.31) | 0.69 (0.98) | − 0.29 (2)*** | 0 (1.96)** |
| Temporal | 0.7 (1.01) | 0 (1.67) | 0 (2.07)** | 0 (1.74) |
| Temporal inferior | 0 (1.7) | 0 (1.84) | − 0.11 (3) | 0 (2.76) |
| Temporal superior | 0.31 (1.89) | 0.65 (1.6) | 0 (2.49)* | − 0.05 (3.67) |
| Nasal | 0 (1.79) | 0.76 (1.4) | − 0.63 (2.13)* | 0 (2.36) |
| Nasal inferior | 0.05 (2.31) | 0.7 (1.8) | − 1.06 (2.4)*** | 0 (2.35)* |
| Nasal superior | 0 (2.16) | 0.41 (2.19) | − 0.53 (3)* | 0 (2.46) |
| Median rate of change in macular volume in mm3/year (IQR) | ||||
|---|---|---|---|---|
| Healthy volunteers | Participants with MS | |||
| OS | OD | OS | OD | |
| 0.001 (0.092) | 0.012 (0.086) | − 0.028 (0.077)** | − 0.02 (0.087)** | |
OS, Left eye; OD, Right eye; ON, Optic neuritis; MS, Multiple sclerosis; SD, Standard deviation.
p values: * < 0.05; ** < 0.01; *** < 0.001.