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. 2022 Nov 28;12:20435. doi: 10.1038/s41598-022-24716-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of SA10SC-RLX and relaxin on renal blood flow and renal vascular resistance in anesthetized SD rat. Effects of IV administration of SA10SC-RLX (blue curves) or relaxin (orange and red curves) on mean Renal Blood Flow (RBF) (a, c) and renal vascular resistance (RVR) (b, d) in anesthetized SD rats. Results are expressed as mean ± SEM of changes from baseline for each animal (n = 8/group). A two-way analysis of variance was performed on rank-transformed data for both mean RBF and RVR, followed by two-tailed Dunnett's test, versus vehicle for group factor (*P < 0.05; **P < 0.01; ***P < 0.001).