Table 1.

In vitro potency and amino acid sequence of glepaglutide analytes and hGLP-2

EC⁵⁰ half maximal effective concentration, hGLP-2 human glucagon-like peptide-2, M1 main glepaglutide metabolite 1, M2 main glepaglutide metabolite 2

Red letters represent amino acid substitutions; green letters represent amino acid additions

^aIn vitro potencies as determined by quantifying cAMP accumulation in a cell line stably overexpressing the hGLP-2 receptor