Table 5.

Characteristics of nodules, overall and stratified by with and without emphysema (n = 424)

Variables	Overall (n = 424)	With emphysema (n = 283)	Without emphysema (n = 141)	p value
Nodule volume (mm3) Median (Q25, Q75)	69 (43, 143)	74 (45, 152)	62 (41, 112)	0.03*
Nodule number				< 0.01**
1	283 (66.7%)	174 (61.5%)	109 (77.3%)#
2–3	115 (27.1%)	91 (32.2%)	24 (17.0%)#
≥ 4	26 (6.1%)	18 (6.4%)	8 (5.7%)
Nodule classification				0.47**
Solid	385 (90.8%)	254 (89.8%)	131 (92.9%)
Part solid	11 (2.6%)	9 (3.2%)	2 (1.4%)
Non-solid	28 (6.6%)	20 (7.1%)	8 (5.7%)
Nodule location				0.70**
Upper lobe	223 (52.6%)	147 (51.9%)	76 (53.9%)
Lower lobe	201 (47.4%)	136 (48.1%)	65 (46.1%)

Note: *Based on Mann-Whitney U testing; **based on chi-square testing. ^#p < 0.01 vs. with emphysema; if multiple nodules were detected, the largest one was shown

Significant p values are marked in bold