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. 2022 Oct 20;48(12):1709–1725. doi: 10.1007/s00134-022-06884-x

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© The Author(s) 2022, corrected publication 2023

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Fig. 3 — Tensor cubic spline for the interaction between PaO_2max and FiO_2max with GFAP in CENTER-TBI. In A on the left, we represented the tensor cubic spline with 4 degrees of freedom each, used for the interaction between PaO_2max and GFAP in the logistic model with 6-month mortality as outcome. In B on the right, we represented the tensor cubic spline with 4 degrees of freedom each, used for the interaction between FiO_2max and GFAP in the logistic model with 6-month mortality as outcome. All other continuous covariates were set to median values and mid-category for categorical ones