Table 2.
Multivariable models on GOSE and mortality at 6-month follow-up in CENTER-TBI (Models 1, 2, 3 and 4)
| CENTER-TBI | 6-month GOSE N = 912 patients, 489 GOSE≤4 |
6-month mortality N = 912 patients, 225 died |
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|---|---|---|---|---|---|---|
| Model 1 | OR* | 95% CI | p | OR* | 95% CI | p value |
| PaO2max (for 10 mmHg increase) | 1.02 | 1–1.04 | 0.014 | 1.03 | 1.01–1.05 | 0.002 |
| PaO2mean (for 10 mmHg increase) | 1.03 | 1–1.07 | 0.059 | 1.08 | 1.04–1.13 | < 0.001 |
| ΔPaO2mean (for 10 mmHg increase)b | 1.07 | 1.03–1.12 | 0.001 | 1.14 | 1.08–1.20 | < 0.001 |
| 6-month GOSE N = 764 patients, 407 GOSE≤4 |
6-month mortality N = 764 patients, 175 died |
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|---|---|---|---|---|---|---|
| Model 2 | OR* | 95% CI | p | OR* | 95% CI | p |
| Logarithm GFAP | 1.51 | 1.33–1.71 | < 0.001 | 1.51 | 1.29–1.77 | < 0.001 |
| PaO2max (for 10 mmHg increase) | 1.02 | 1–1.03 | 0.064 | 1.03 | 1.01–1.05 | 0.008 |
| Logarithm GFAP | 1.52 | 1.34–1.72 | < 0.001 | 1.52 | 1.3–1.78 | < 0.001 |
| PaO2mean (for 10 mmHg increase) | 1.03 | 0.99–1.07 | 0.092 | 1.09 | 1.04–1.14 | 0.001 |
| Logarithm GFAP | 1.52 | 1.34–1.72 | < 0.001 | 1.53 | 1.3–1.81 | < 0.001 |
| ΔPaO2mean (for 10 mmHg increase) | 1.05 | 1–1.11 | 0.031 | 1.14 | 1.08–1.21 | < 0.001 |
| 6-month GOSE N = 877 patients, 470 GOSE≤4 |
6-month mortality N = 877 patients, 212 died |
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|---|---|---|---|---|---|---|
| Model 3 | OR*** | 95% CI | p | OR*** | 95% CI | p |
| FiO2max (for 0.1 increase) | 1.03 | 0.96–1.1 | 0.453 | 1.18 | 1.08–1.29 | < 0.001 |
| FiO2mean, (for 0.1 increase) | 1.02 | 0.92–1.14 | 0.694 | 1.31 | 1.13–1.51 | < 0.001 |
| ΔFiO2mean, (for 0.1 increase) | 1.03 | 0.84–1.27 | 0.761 | 1.46 | 1.13–1.88 | 0.004 |
| 6-month GOSE N = 741 patients, 397 GOSE≤4 |
6-month mortality N = 741 patients, 168 died |
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|---|---|---|---|---|---|---|
| Model 4 | OR* | 95% CI | p | OR* | 95% CI | p |
| Logarithm GFAP | 1.52 | 1.34–1.72 | < 0.001 | 1.55 | 1.31–1.83 | < 0.001 |
| FiO2max (for 0.1 increase) | 1.03 | 0.96–1.12 | 0.389 | 1.20 | 1.08–1.33 | 0.001 |
| Logarithm GFAP | 1.52 | 1.34–1.72 | < 0.001 | 1.55 | 1.32–1.84 | < 0.001 |
| FiO2mean (for 0.1 increase) | 1.04 | 0.93–1.17 | 0.498 | 1.33 | 1.13–1.55 | < 0.001 |
| Logarithm GFAP | 1.51 | 1.33–1.72 | < 0.001 | 1.55 | 1.31–1.83 | < 0.001 |
| ΔFiO2mean (for 0.1 increase) | 0.98 | 0.78–1.23 | 0.846 | 1.40 | 1.05–1.87 | 0.023 |
Model 1. Adjusted odds ratio with 95% confidence intervals of exposure to high blood oxygen levels within 7 days of ICU admission on GOSE and mortality at 6-month follow-up in CENTER-TBI. Mixed-effect logistic regression models adjusted for age, pupillary reactivity (both reactive, one reactive, both unreactive), GCS motor (any flexion, none/extension, localizes/obey), Injury Severity Score, and, once at a time, PaO2max, PaO2mean and ΔPaO2mean for CENTER-TBI with center as a random effect. Model 2. Model 1 plus the degree of brain injury quantified as GFAP levels. Model 3. Adjusted odds ratio with 95% CI of GOSE and mortality at 6-month follow-up in TBI patients exposed to high supplemental oxygen administration within 7 days of ICU admission in CENTER-TBI. Mixed-effect logistic regression models adjusted for age, pupillary reactivity (reactive, one reactive, both unreactive), GCS motor (any flexion, none/extension, localizes/obey) and, once at a time, FiO2max, FiO2mean and ΔFiO2mean for CENTER-TBI with center as a random effect. Full models with all covariates estimates are reported in the Supplemental material. Model 4. Model 3 plus the degree of brain injury quantified as GFAP levels
aOR is for 10 mmHg increase in PaO2 covariate
b1 patient did not have low PaO2
cOR regards 0.1 increments in FiO2 covariate