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. 2022 Nov 28;12:493. doi: 10.1038/s41398-022-02197-1

Table 4.

Microglia sequelae: evidences from neurodevelopment until adulthood in others schizophrenia animal models.

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Other schizophrenia animal models Adolescence Adulthood
PND 28 PND 35 PND 56 PND 60–100

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Wistar rats

LPS injection

GD 17 until delivery

No changes in density (hip)

♂ and ♀

[112]

 – – –

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Wistar rats

single poly I:C injection PND5-7

 –

↑ Microglia activation

↑ Inflammation

(PFC, striatum and hip)

[116]

 –

↑ Microglia activation

↑ Inflammation

(PFC, striatum and hip)

[116, 124]

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Gunn and Wistar rats

 – –

Only ♂

↑ Microglia activation

Similar microglia density

Microglia with enlarged areas of cytoplasm rich in organelles and some phagocytic pouches

(hip)

[121, 122]

 –

PND post natal day, PFC prefrontal cortex, hip hippocampus.