TABLE 2.
Univariate and multivariate Cox regression analysis of clinicopathological characteristics associated with progression-free survival (PFS) in colorectal cancer (CRC) patients.
| Characteristic | Progression-free survival | |||
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| Univariate analysis | Multivariate analysis | |||
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| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Gender (Female) | 1.014 (0.862–1.193) | 0.866 | ||
| Age (≥60 years) | 1.28 (1.093–1.499) | 0.002 | 1.32 (1.122–1.554) | 0.001 |
| BMI | 0.108 | 0.783 | ||
| Low | Ref. | Ref. | ||
| Normal | 0.871 (0.694–1.095) | 0.237 | 0.938 (0.741–1.187) | 0.595 |
| High | 0.762 (0.589–0.986) | 0.038 | 0.91 (0.697–1.188) | 0.486 |
| Hypertension (Yes) | 1.198 (0.979–1.466) | 0.079 | ||
| Diabetes (Yes) | 1.152 (0.845–1.57) | 0.371 | ||
| NAR (High) | 1.703 (1.396–2.077) | <0.001 | 1.280 (1.031–1.589) | 0.025 |
| T stage (T3–4) | 2.364 (1.896–2.947) | <0.001 | 1.426 (1.123–1.811) | 0.004 |
| N stage | <0.001 | <0.001 | ||
| N0 | Ref. | Ref. | ||
| N1 | 1.872 (1.553–2.257) | <0.001 | 1.531 (1.261–1.859) | <0.001 |
| N2 | 4.055 (3.338–4.927) | <0.001 | 2.798 (2.254–3.472) | <0.001 |
| Distant metastasis (Yes) | 5.384 (4.411–6.572) | <0.001 | 3.048 (2.442–3.805) | <0.001 |
| Tumor location (Colon) | 0.918 (0.784–1.075) | 0.287 | ||
| Tumor size (≥5 cm) | 1.192 (1.019–1.395) | 0.028 | 0.96 (0.814–1.132) | 0.627 |
| Perineural invasion (Positive) | 1.755 (1.403–2.195) | <0.001 | 1.127 (0.877–1.447) | 0.352 |
| Vascular invasion (Positive) | 1.997 (1.663–2.397) | <0.001 | 1.21 (0.978–1.496) | 0.080 |
| Macroscopic type | 0.003 | 0.313 | ||
| Protrude type | Ref. | |||
| Infiltrating type | 1.466 (1.075–1.998) | 0.016 | 1.214 (0.887–1.662) | 0.225 |
| Ulcerative type | 1.366 (1.129–1.653) | 0.001 | 1.151 (0.944–1.403) | 0.165 |
| Differentiation (High/Medium) | 0.7 (0.563–0.869) | 0.001 | 0.869 (0.693–1.091) | 0.228 |
| Surgical approach (Laparoscope) | 0.673 (0.575–0.788) | <0.001 | 0.882 (0.741–1.051) | 0.161 |
| Operating time (median) (≥192 min) | 1.205 (1.029–1.412) | 0.021 | 1.048 (0.887–1.239) | 0.581 |
| Blood loss (median) (≥100 ml) | 1.246 (1.052–1.477) | 0.011 | 1.078 (0.901–1.291) | 0.412 |
| CEA (≥5 ng/ml) | 1.988 (1.698–2.328) | <0.001 | 1.474 (1.245–1.746) | <0.001 |
| Radiotherapy (Yes) | 1.151 (0.885–1.496) | 0.293 | ||
| Chemotherapy (Yes) | 1.141 (0.974–1.336) | 0.101 | ||
CRC, colorectal cancer; BMI, body mass index; NAR, neutrophil-albumin ratio.