TABLE 3.

Univariate and multivariate Cox regression analysis of clinicopathological characteristics associated with overall survival (OS) in colorectal cancer (CRC) patients.

Characteristic	Overall survival
	Univariate analysis		Multivariate analysis
	HR (95% CI)	P-value	HR (95% CI)	P-value
Gender (Female)	1.013 (0.857–1.198)	0.881
Age (≥60 years)	1.344 (1.141–1.583)	<0.001	1.356 (1.145–1.606)	<0.001
BMI		0.060		0.579
Low	Ref.		Ref.
Normal	0.858 (0.678–1.085)	0.200	0.919 (0.721–1.171)	0.492
High	0.73 (0.56–0.952)	0.020	0.864 (0.656–1.138)	0.299
Hypertension (Yes)	1.202 (0.976–1.48)	0.084
Diabetes (Yes)	1.188 (0.865–1.632)	0.287
NAR (High)	1.769 (1.444–2.167)	<0.001	1.280 (1.026–1.596)	0.029
pT stage (T3–4)	2.495 (1.975–3.151)	<0.001	1.464 (1.138–1.885)	0.003
pN stage		<0.001		<0.001
N0	Ref.		Ref.
N1	1.875 (1.544–2.277)	<0.001	1.519 (1.242–1.859)	<0.001
N2	4.079 (3.339–4.983)	<0.001	2.658 (2.127–3.32)	<0.001
Distant metastasis (Yes)	5.609 (4.581–6.866)	<0.001	3.186 (2.546–3.987)	<0.001
Tumor location (Colon)	0.976 (0.83–1.149)	0.772
Tumor size (≥5 cm)	1.308 (1.112–1.539)	0.001	1.069 (0.901–1.267)	0.444
Perineural invasion (Positive)	1.713 (1.359–2.159)	<0.001	1.075 (0.829–1.393)	0.587
Vascular invasion (Positive)	2.039 (1.691–2.459)	<0.001	1.256 (1.01–1.562)	0.041
Macroscopic type		0.006		0.399
Protrude type	Ref.
Infiltrating type	1.448 (1.05–1.997)	0.024	1.175 (0.848–1.627)	0.333
Ulcerative type	1.366 (1.12–1.665)	0.002	1.147 (0.934–1.409)	0.192
Differentiation (High/Medium)	0.648 (0.521–0.807)	0.001	0.789 (0.627–0.993)	0.044
Surgical approach (Laparoscope)	0.648 (0.551–0.763)	<0.001	0.89 (0.743–1.066)	0.207
Operating time (median) (≥192 min)	1.21 (1.028–1.426)	0.022	1.075 (0.904–1.278)	0.413
Blood loss (median) (≥100 ml)	1.263 (1.059–1.506)	0.009	1.104 (0.916–1.331)	0.298
CEA (≥5 ng/ml)	2.036 (1.73–2.397)	<0.001	1.472 (1.236–1.754)	<0.001
Radiotherapy (Yes)	0.939 (0.705–1.252)	0.67
Chemotherapy (Yes)	1.047 (0.889–1.233)	0.581

CRC, colorectal cancer; BMI, body mass index; NAR, neutrophil-albumin ratio.