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. 2022 Nov 15;13:1040999. doi: 10.3389/fphar.2022.1040999

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Copyright © 2022 Lin, Lin, Lai, Han, Fan, Tang, Mo, Su, Liang, Shang, Lv, Guo, Pang, Zhou, Zhang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ob/ob mice and lean mice had similar macrophage infiltration and inflammatory factor levels in liver with or without ponatinib. (A) Representative image of F4/80 immunostaining of liver sections of ob/ob mice and lean mice administrated with ponatinib or vehicle. n = 5. (B) Relative macrophage area of each group from (A) n = 5. (C–E) IL-1β, IL-6, and IL-10 mRNA transcription from liver of ob/ob mice and lean mice treated with or without ponatinib measured by qPCR. n = 5. Statistical comparisons were performed with one-way ANOVA (B–D) followed by Bonferroni’s multiple comparisons post hoc test. Data represent mean ± SEM.