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. 2022 Nov 15;13:1042916. doi: 10.3389/fmicb.2022.1042916

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Copyright © 2022 Ren, Pei, Jiang, Zhao, Jiang, Liu, Yi, Hui and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of safety of the recombinant WM01ma-HA (H5) influenza virus as indicated by weight changes of experimental mice (A) and HAI titers against the HN021ma influenza virus (B) and the WM01ma influenza virus (C). Each symbol represents an individual mouse, and the horizontal lines indicate mean values. The differences between the two groups were analyzed by a one-way ANOVA with Tukey's multiple-comparison test. ns indicates not significant. (p > 0.05), *(p ≤ 0.05), **(p ≤ 0.01), ****(p ≤ 0.0001).