Fig. 3.

Front-view clinical image before starting treatment with IL-STS, showing erythema and increased volume of the patient’s left elbow (a). Front-view clinical image 4 months after IL-STS therapy was initiated—after four injections of IL-STS, where a remarkable improvement of the inflammatory signs can be noticed (b). A central crust is observed, which was an adverse event of the IL-STS injection (b). Cutaneous ultrasound image (22 MHz probe) of her left elbow, before starting treatment with IL-STS, showing multiple hyperechoic images (yellow arrows) and positive Doppler signal (c). Cutaneous ultrasound image (22 MHz probe) of her left elbow, 4 months after IL-STS therapy was initiated, where only some small calcifications (yellow arrows) with negative Doppler signal were objectivated (d)