Figure 4.

Performance evaluation and validation of the TIS in HCC. (A) Differential correlation distribution of clinical traits between high- and low-risk groups in TCGA database (left) and ICGC database (right). (B) Distribution of risk score, survival status, and expressed profiles of TIS genes in low- and high-risk groups from TCGA training dataset and ICGC validation dataset. (C) Risk score and mortality rate of patients in high- and low-risk groups in two datasets. (D) KM plots of OS showing the discriminated survival between high- and low-risk groups in two datasets. ROC curves with AUC values (E) and calibration plots (F) were employed to elaborate TIS performance in two datasets. (G) Distinct 3- and 5-year AUC of TIS and several published signatures. TCGA, The Cancer Genome Atlas; ICGC, International Cancer Genome Consortium; ROC, receiver operating characteristic; AUC, the area under the ROC curve; ****P < 0.0001.