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. 2022 Nov 15;13:974377. doi: 10.3389/fimmu.2022.974377

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Copyright © 2022 Luo, Liu, Fu, Ding and Teng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distinct carcinogenetic mechanisms between TIS-high and TIS-low groups. (A) Bar graph for the differential enrichment in carcinogenetic pathways, determined by GSVA, between the TIS-high and TIS-low groups. Bubble plot (B) and ridge plot (C) for the differential enrichment in carcinogenetic pathways, determined by GSEA, between the TIS-high and TIS-low groups. (D) GSEA enrichment plots showing significantly enriched pathways including six upregulated and three downregulated pathways. (E) KM plots of OS delineating the prognostic landscapes of the four typical oncogenic pathways. GSVA, gene set variation analysis; GSEA, gene set enrichment analysis.