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. 2022 Nov 15;13:974377. doi: 10.3389/fimmu.2022.974377

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Copyright © 2022 Luo, Liu, Fu, Ding and Teng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation of TIS with immune infiltration, immune checkpoint genes, and immunomodulatory genes. (A) The boxplot for the alteration of 28 immune cells between the TIS-high and TIS-low groups. Differential leukocyte fraction (B), MDSC (C), and CTL exclusion score (D) between the TIS-high and TIS-low groups. Heatmap (E) and chordal graph (F) for the correlation of the common immune checkpoint genes, including PD1, CTLA4, PD-L1, and PD-L2, with TIS and TIS genes. The correlation of TIS with 25 immune checkpoint genes (G) and 50 immunomodulatory genes (H); *P < 0.05; **P < 0.01; ***P < 0.001;****P < 0.0001; ns, no significance.