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. 2022 Nov 15;13:974377. doi: 10.3389/fimmu.2022.974377

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Copyright © 2022 Luo, Liu, Fu, Ding and Teng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Predictive potential of TIS for immunotherapy response. Violin plots for the correlation of TIS with the four IPS (A) and ITH (B). Scatterplots for the correlation of TIS with LOH (C) and HRD (D). (E) The distinct prognostic pattern of TIS in immunotherapy data. Boxplot (F) and bar plot (G) for the differential immunotherapy response between the TIS-high and TIS-low groups. IPS, immunophenoscore; ITH, intratumor heterogeneity; LOH, loss of heterozygosity; HRD, homologous recombination deficiency.