Fig. 1. Low-molecular-weight collagen peptide (LMCP) ameliorated cartilage damage associated with osteoarthritis in the anterior cruciate ligament transection (ACLT) model.

Rabbits underwent ACLT or sham operation and received treatment with vehicle or LMCP at 100 (100 LMCP) or 200 mg/kg (200 LMCP) by oral gavage once daily for 12 weeks. (A) Representative hematoxylin and eosin (H&E) and Safranin O images of cartilage (magnification, ×100). (B) OARSI score of cartilage. Data are presented as the mean ± SD (n = 8), and data were analyzed via one-way analysis of variance followed by Duncan’s test. ^###p < 0.001 compared with the sham group. *p < 0.05 and **p < 0.01 compared with the ACLT group.