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. 2021 Sep 11;31(10):1401–1408. doi: 10.4014/jmb.2108.08027

Fig. 2. Low-molecular-weight collagen peptide (LMCP) inhibited subchondral bone damage associated with osteoarthritis in the rabbit anterior cruciate ligament transection (ACLT) model.

Fig. 2

Rabbits underwent ACLT or sham operation and received treatment with vehicle or LMCP at 100 (100 LMCP) or 200 mg/kg (200 LMCP) by oral gavage once daily for 12 weeks. (A) Representative micro-computed tomography (CT) images of subchondral bone. Quantitative micro-CT analysis of femoral (B) and tibial (C) subchondral bone. BV/TV, trabecular bone volume per total volume; BS/BV, trabecular bone surface per bone volume; TbN, trabecular number; TbSp, trabecular separation; TbTh, trabecular thickness. Data are presented as the mean ± SD (n = 8), and were analyzed via one-way analysis of variance followed by Duncan’s test. #p < 0.05, ##p < 0.01, and ###p < 0.001 compared with the sham group. *p < 0.05 and **p < 0.01 compared with the ACLT group.