Fig. 2. Large-scale prodigiosin production.

Prodigiosin was produced by H. chejuensis under optimal conditions, and about 50 g/l cell pellet was obtained. 261 g total amount was obtained as freeze-dried crude prodigiosin produced from the optimized cultivated H. chejuensis. Finally, prodigiosin purified from fermentation cultures in the scaled-up 200 L bioreactor system was obtained at 99.5% purity.