Table 4.

Repeat patterns of EPIYA in the 3'-region of cagA of H. pylori isolates recovered from patients with chronic gastritis, peptic ulcer, or gastric cancer.

CagA EPIYA types a	Chronic gastritis (n=38)	Peptic ulcer (n=39)	Gastric cancer (n=39)
ABD or A′bD	35 (92.0%)	38 (97.4%)	35 (89.7%)
ABD′bD or A′bD′bD	0	1 (2.6%)	3 (7.7%)
ABABD	1 (2.7%)	0	1 (2.6%)
CagA negative	2 (5.3%)	0	0

^a, A, B, and D indicate typical EPIYA segment, b notes the EPIYA-B segment deleted in the 5’-end region including EPIYA motif, and A′ and D′ indicate the segment deleted in the downstream region of EPIYA motif. ABD segments produced DNA fragments of 293~299 bp with cagA EPIYA FR primers and 222 bp with EPIYA JSR primers. When amplified DNAs of different sizes were produced, amplified DNAs were subjected to nucleotide sequence analysis.