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. 2022 Nov 15;13:942129. doi: 10.3389/fphar.2022.942129

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Copyright © 2022 Huang, Lin, Wang, Chen, Zheng, Zhong, Shang, Huang, Gao, Deng, Li, Zeng and Mo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Goodness-of-fit plots for the final model. (A) Observed concentrations (DV) vs. individual predictions (IPRED); (B) DV vs. population predictions (PRED); (C) conditional weighted residuals (CWRES) vs. PRED; (D) CWRES vs. Time). As shown in figures (A,B), the scatter points generated by the final model are evenly distributed on both sides of the reference line; as shown in figures C and D, the residual scatter points are symmetrically distributed. Most of them are in the range of (−2 ∼ + 2), which proves that there is no obvious bias in the prediction error.