TABLE 3.
Parameter estimation results and bootstrap results of the final population pharmacokinetic model.
| Parameter | Final model | Bootstrap | ||
|---|---|---|---|---|
| Estimate (shrinkage %) | CV% | Median | 95% CI | |
| tvV(L) | 192.03 | 18.76 | 192.03 | 126.72–289.71 |
| vbtvCL (L/h) | 10.54 | 6.81 | 10.38 | 7.55–14.21 |
| dCLdAGE | 0.31 | 12.95 | 0.31 | 0.22–0.39 |
| dCLdCTLA4 GA | −0.34 | −18.21 | −0.33 | −0.63 ∼ −0.01 |
| dCldCTLA4 AA | −0.15 | −28.96 | −0.15 | −0.43–0.18 |
| dCLdCYP3A5 *3/*3 | −0.25 | −19.07 | −0.25 | −0.36 ∼ −0.15 |
| dCLdCombWZ | −0.34 | −25.96 | −0.34 | −0.52 ∼ −0.15 |
| Inter-individual variability | ||||
| ω2 V (%) | 1.13 (38.09) | 5.53 | 1.13 | — |
| ω2 CL (%) | 0.13 (30.02) | 6.03 | 0.13 | — |
| Residual variability | ||||
| σ (%) | 29.95 | 4.75 | 0.30 | 0.27–0.33 |
CV%, percent confidence of variation; CI, confidence interval; tvV, typical value of apparent distribution; tvCL, typical value of apparent volume clearance; dCLdAGE, fixed parameter coefficient of age to CL; dCLdCTLA4 GA, fixed parameter coefficient of CTLA4 GA to CL; dCldCTLA4 AA, fixed parameter coefficient of CTLA4 AA to CL; dCLdCYP3A5 *3/*3, fixed parameter coefficient of CYP3A5 *3/*3 to CL; dCLdCombWZ, fixed parameter coefficient of WuZhi capsules to CL; ω2 V, variance of interindividual variability for V; ω2 CL, variance of interindividual variability for CL; σ, square root of residual variability for the final model.