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. 2021 Sep 11;31(11):1508–1518. doi: 10.4014/jmb.2106.06031

Fig. 4.

Fig. 4

MiR-661 was overexpressed in NSCLC tissues and cells and participated in the regulation of circ_0001947 on cell viability. A. The level of miR-661 in 40 NSCLC tissues and adjacent non-tumor tissues was analyzed by qRT-PCR. U6 was used as the internal control. (&&&p < 0.001 vs. normal) B. The level of miR-661 in NSCLC cells and normal cells was analyzed by qRT-PCR. U6 was used as the internal control. (###p < 0.001 vs.16HBE) C. The effects of circ_0001947 knockdown and miR- 661 inhibitor (I) on the level of miR-661 were analyzed by qRT-PCR. U6 was used as the internal control. (***p < 0.001 vs. si-NC + inhibitor control (IC) group; △△△p < 0.001 vs. small interfering RNA targeting circ_0001947 (si-circ_0001947#2) + IC group; ‡‡ p < 0.01 vs. si-NC + I group) D. The effects of circ_0001947 overexpression and miR-661 mimic (M) on the level of miR-661 were analyzed by qRT-PCR. U6 was used as the internal control. (^^^p <0.001 vs. NC + MC group; †††p <0.001 vs. NC + M group; ΦΦΦ p <0.001 vs. circ_0001947 + MC group) E. The effects of circ_0001947 knockdown and miR-661 I on cell viability were analyzed by CCK-8. (*p < 0.05, ** p < 0.01 vs. si-NC + IC group; △p <0.05 vs. si-circ_0001947#2 + IC group; ‡ p < 0.05 vs. si-NC + I group) F. The effects of circ_0001947 overexpression and miR-661 M on cell viability were analyzed by CCK-8. (^p < 0.05, ^^^ p < 0.001 vs. NC + MC group; ΦΦ p < 0.01, ΦΦΦ p < 0.001 vs. circ_0001947 + MC group; †p < 0.05 vs. NC + M group)