Fig. 3. Effect of resveratrol, β-piceid and α-piceid isomers on cellular tyrosinase activity in α-MSHstimulated B16F10 melanoma cells.

The cells were treated with α-MSH alone or together with arbutin, resveratrol, β- piceid, or α-piceid isomers for 48 h and then cellular tyrosinase activity was measured. Significant differences were compared with α-MSH treated cells: **p < 0.005 and ***p < 0.001, significant differences were also observed between β-piceid and α-piceid isomers: #p < 0.05 and ###p < 0.001.