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. 2022 Nov 22;18:17448069221094528. doi: 10.1177/17448069221094528

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This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — rpVEGF induces mechanical and thermal hyperalgesia. (A). Effect of Vascular endothelial growth factor A (rpVEGFA) on the paw withdrawal mechanical threshold (PWMT). After 1 ng, 10 ng and 100 ng rpVEGFA i.t. injection, the PWMT was significantly decreased when compared to control mice; (B). Effect of rpVEGFA on the paw withdrawal thermal latency (PWTL). Compared with the control group, the PWTL was dramatically reduced after 1 ng, 10 ng and 100 ng rpVEGFA i.t. injection. The results were analyzed by One-way analysis of variance (ANOVA) and by multiple comparisons. (n = 6). * p < 0.05, ** p < 0.01, and *** p < 0.001.