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. 2022 Nov 22;18:17448069221094528. doi: 10.1177/17448069221094528

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© © The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Differential expression of inflammatory biomarkers in each group. (a–b) IL-6, TNF-α, and IL-1β in the spinal cord were detected by WB. The expressions of inflammatory biomarkers showed a similar tendency as SNI-induced hyperalgesia in each group. After SNI surgery, the IL-6, TNF-α, and IL-1β expression were significantly increased (red bar, b), sFlt1 inhibited the expression of IL-6, TNF-α, and IL-1β (green bar, b), and rpVEGFA inhibited the sFIt1-induced downregulation of the inflammatory biomarkers (blue bar, b). The data are shown as the mean ± SEM (n = 3). The results were analyzed by One-way analysis of variance ANOVA and by multiple comparisons. ⁎ p < .05, ⁎⁎ p < .01, and ⁎⁎⁎ p < .001.