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. 2022 Nov 15;13:1046894. doi: 10.3389/fmicb.2022.1046894

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Copyright © 2022 Duan, Wang, Jiang, Bai and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of metabolites profile of neurotransmitters from mice fecal. (A) Principal component analysis (PCA) Scores plot between the two groups. The explained variances are shown in brackets. (B) Volcano plot for differential metabolites. Significantly regulated metabolites between groups determined by fold change and value of p (FC>|1.5|, p < 0.05). Red dots represent increased metabolites in CON group; blue dots represent decreased metabolites in CON group. (C) Heatmap of all neurotransmitters; differential metabolites were indicated by an asterisk. (D) Pathway enrichment analysis of differential metabolites.