. 2022 Nov 21;26:100557. doi: 10.1016/j.bbih.2022.100557

Table 3.

The top ten significant interactions of gut microbiome PRS and IBD PRS on depression in different sex.

	Depression phenotypes	IBD phenotypes	Gut microbiome	Gut microbiome PRS		IBD PRS		Interaction
	Depression phenotypes	IBD phenotypes	Gut microbiome	T	P	T	P	T	P
Male
	PHQ-9 score	CD + UC	F_Ruminococcaceae_RNT	2.844	0.004	3.210	0.001	−3.202	0.001
	Self-reported depression	UC	G_Phascolarctobacterium_RNT	−3.053	0.002	3.062	0.002	3.027	0.002
	Age at first episode of depression	CD	G_Streptococcus_RNT	0.666	0.506	−2.111	0.035	2.854	0.004
	Age at first episode of depression	CD + UC	G_Faecalitalea_HB	2.520	0.012	−2.483	0.013	−2.781	0.005
	PHQ-9 score	UC	F_Ruminococcaceae_RNT	2.582	0.010	2.683	0.007	−2.725	0.006
	Self-reported depression	CD	C_Gammaproteobacteria_HB	0.757	0.449	−0.922	0.357	−2.724	0.006
	Age at first episode of depression	UC	F_Erysipelotrichaceae_HB	−2.335	0.020	−2.254	0.024	2.614	0.009
	Age at first episode of depression	UC	C_Actinobacteria_RNT	−2.603	0.009	−1.644	0.100	2.534	0.011
	Self-reported depression	CD + UC	G_Acidaminococcus_HB	2.288	0.022	2.695	0.007	−2.514	0.012
	Age at first episode of depression	UC	G_Faecalitalea_HB	2.376	0.018	−1.897	0.058	−2.464	0.014
Female
	Self-reported depression	UC	G_Sporobacter_HB	−2.996	0.003	−2.423	0.015	3.419	0.001
	Age at first episode of depression	CD	G_Eisenbergiella_RNT	−1.712	0.087	2.230	0.026	−2.868	0.004
	Self-reported depression	CD	F_Erysipelotrichaceae_RNT	0.190	0.849	−1.016	0.310	−2.776	0.006
	Self-reported depression	CD + UC	F_Erysipelotrichaceae_RNT	2.736	0.006	−0.290	0.771	−2.689	0.007
	PHQ-9 score	CD + UC	G_Intestinibacter_HB	2.309	0.021	0.502	0.616	−2.679	0.007
	PHQ-9 score	CD + UC	O_Bacteroidales_HB	2.051	0.040	1.026	0.305	−2.663	0.008
	Depression possibly related to childbirth	CD	G_Anaerostipes_RNT	1.079	0.281	−0.273	0.785	−2.628	0.009
	PHQ-9 score	CD	G_Intestinibacter_HB	−0.652	0.514	0.696	0.487	−2.599	0.009
	Age at first episode of depression	UC	G_Barnesiella_HB	−2.208	0.027	−2.234	0.025	2.566	0.010
	Self-reported depression	CD + UC	G_Sporobacter_HB	−1.860	0.063	−2.039	0.041	2.529	0.011

Notes: C, Class. O, Order. F, Family. G, Genus. PRS: Polygenic risk scores. PHQ: Patient Health Questionnaire. IBD: Inflammatory bowel disease. UC: Ulcerative colitis. CD: Crohn's disease.